|
|
Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine <=> H+ + lipid_II + UDP
|
2.4.1.227
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
|
–
|
BMK
|
|
BRENDA:
BR44201
KEGG:
R05662;
R06173
MetaCyc:
RXN-8976
|
|
|
|
lipid_II + ATP <=> beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + ADP
|
6.3.5.13
lipid II isoglutaminyl synthase (glutamine-hydrolysing)
|
–
|
|
|
BRENDA:
BR52713
KEGG:
R12330
MetaCyc:
RXN-11339
|
|
|
|
lipid_I + UDP-N-acetyl-D-glucosamine <=> H+ + lipid_II + UDP
|
2.4.1.227
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
|
–
|
MK
|
|
BRENDA:
BS378301
KEGG:
R05032;
R06174
MetaCyc:
NACGLCTRANS-RXN
|
|
|
|
L-glutamine + lipid_II + ATP + H2O <=> L-glutamate + lipid_II + ADP + phosphate + H+
|
6.3.5
6.3.5.13
lipid II isoglutaminyl synthase (glutamine-hydrolysing)
|
–
–
|
M
|
|
KEGG:
R08855
MetaCyc:
RXN-20088
|
|
|
|
beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + NH3 <=> lipid_II + phosphate
|
6.3.5.13
lipid II isoglutaminyl synthase (glutamine-hydrolysing)
|
–
|
|
|
KEGG:
R12331
MetaCyc:
RXN-20091
|
|
|
|
lipid_II <=> undecaprenyl_diphosphate + lipid_II
|
2.4.1.129
peptidoglycan glycosyltransferase
|
–
|
M
|
|
MetaCyc:
2.4.1.129-RXN
|
|
|
|
lipid_II + H2O <=> N-acetylglucosamine--N-acetylmuramyl-(tetrapeptide)_pyrophosphoryl-undecaprenol + D-alanine
|
3.4.16.4
serine-type D-Ala-D-Ala carboxypeptidase
|
–
|
|
|
MetaCyc:
3.4.16.4-RXN
|
|
|
|
lipid_II + D-Aspartate + ATP <=> H+ + [beta-GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-6-N-(beta-D-Asp)-L-Lys-D-Ala-D-Ala)]n + ADP + phosphate
|
6.3.1.12
D-aspartate ligase
|
–
|
|
|
MetaCyc:
6.3.1.12-RXN
|
|
|
|
decaprenyl-diphospho-N-acetylmuramoyl-pentapeptide + UDP-N-acetyl-D-glucosamine <=> H+ + lipid_II + UDP
|
2.4.1.227
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-11029
|
|
|
|
lipid_II + glycyl-[tRNAGly] <=> Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine + tRNAMet + H+
|
2.3.2.16
lipid II:glycine glycyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-11295
|
|
|
|
lipid_II <=> H+ + peptidoglycan_dimer_(mycobacteria) + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl_diphosphate
|
2.4.1
|
–
|
M
|
|
MetaCyc:
RXN-11301
|
|
|
|
lipid_II + L-alanyl-[tRNAAla] <=> ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N6-(L-alanyl)-L-lysyl-D-alanyl-D-alanine + tRNAMet + H+
|
2.3.2.16
lipid II:glycine glycyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-11310
|
|
|
|
lipid_II + D-Aspartate + ATP <=> H+ + ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-isoglutaminyl-N-(beta-D-asparatyl)-L-lysyl-D-alanyl-D-alanine + ADP + phosphate
|
6.3.1.12
D-aspartate ligase
|
–
|
M
|
|
MetaCyc:
RXN-11342
|
|
|
|
peptidoglycan + lipid_II <=> peptidoglycan + undecaprenyl_diphosphate
|
2.4.1.129
peptidoglycan glycosyltransferase
|
–
|
|
|
MetaCyc:
RXN-14712
|
|
|
|
peptidoglycan_with_(L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine)_pentapeptide + lipid_II <=> undecaprenyl_diphosphate + peptidoglycan_with_(L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine)_pentapeptide
|
2.4.1.129
peptidoglycan glycosyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-15521
|
|
|
|
nascent_peptidoglycan_with_(L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine)_pentapeptide + lipid_II <=> nascent_peptidoglycan_with_(L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine)_pentapeptide + undecaprenyl_diphosphate
|
2.4.1.129
peptidoglycan glycosyltransferase
|
–
|
M
|
|
MetaCyc:
RXN-16650
|
|
|
|
polyisoprenyl-wall_teichoate_(B._subtilis_W23) + lipid_II + H2O <=> peptidoglycan-wall_teichoate_complex_(B._subtilis_W23) + undecaprenyl_phosphate + undecaprenyl_diphosphate + H+
|
2.7.8.M1
|
–
|
M
|
|
MetaCyc:
RXN-18030
|
|
|
|
polyisoprenyl-teichoate + lipid_II + H2O <=> peptidoglycan-wall_teichoate_complex + undecaprenyl_phosphate + undecaprenyl_diphosphate + H+
|
2.7.8.M1
|
–
|
|
|
MetaCyc:
RXN-18033
|
|
|
|
polyisoprenyl-minor_wall_teichoate_(B._subtilis_168) + lipid_II + H2O <=> peptidoglycan-minor_wall_teichoate_complex_(B._subtilis_168) + undecaprenyl_phosphate + undecaprenyl_diphosphate + H+
|
2.7.8.M1
|
–
|
M
|
|
MetaCyc:
RXN-18061
|
|
|
|
polyisoprenyl-wall_teichuronate_(B._subtilis_168) + lipid_II + H2O <=> peptidoglycan-teichuronate_complex_(B._subtilis_168) + undecaprenyl_phosphate + undecaprenyl_diphosphate + H+
|
2.7.8.M1
|
–
|
M
|
|
MetaCyc:
RXN-18064
|
|
|
|
peptidoglycan_dimer_(generic) <=> lipid_II + GlcNAc-1,6-anhydro-MurNAc-pentapeptide
|
4.2.2.M5
|
–
|
|
|
MetaCyc:
RXN0-5190
|
|
|
|
polyisoprenyl-major_wall_teichoate_(B._subtilis_168) + lipid_II + H2O <=> peptidoglycan-major_wall_teichoate_complex_(B._subtilis_168) + undecaprenyl_phosphate + undecaprenyl_diphosphate + H+
|
2.7.8.M1
|
–
|
M
|
|
MetaCyc:
TEICHOICSYN8-RXN
|
|
|
|
lipid_II <=> lipid_II
|
not assigned
|
–
|
|
|
MetaCyc:
TRANS-RXN0-286
|
|
|
|
lipid_II + glycyl-tRNAGly <=> N-acetylmuramoyl-L-alanyl-D-isoglutaminyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + tRNAMet
|
2.3.2.16
lipid II:glycine glycyltransferase
|
–
|
B
|
|
BRENDA:
BR49239
|
|